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Journal article

ALIX regulates tumor-mediated immunosuppression by controlling EGFR activity and PD-L1 presentation

Abstract:

The immunosuppressive transmembrane protein PD-L1 was shown to traffic via the multivesicular body (MVB) and to be released on exosomes. A high-content siRNA screen identified the endosomal sorting complexes required for transport (ESCRT)-associated protein ALIX as a regulator of both EGFR activity and PD-L1 surface presentation in basal-like breast cancer (BLBC) cells. ALIX depletion results in prolonged and enhanced stimulation-induced EGFR activity as well as defective PD-L1 trafficking th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.celrep.2018.06.066

Authors


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Department of Health More from this funder
Engineering and Physical Sciences Research Council More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
24
Issue:
3
Pages:
630-641
Publication date:
2018-07-17
Acceptance date:
2018-06-15
DOI:
EISSN:
2211-1247
Source identifiers:
889501
Keywords:
Pubs id:
pubs:889501
UUID:
uuid:abf24b3b-15d7-4326-b8ad-9450485b2c88
Local pid:
pubs:889501
Deposit date:
2018-07-25

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