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Thesis

The role of nucleoprotein in transcription and replication of the Influenza virus genome

Abstract:

The eight vRNA genome segments of influenza A virus are bound by the viral RNA polymerase at the 5' and 3' ends, and associated with oligomeric nucleoprotein (NP) to form viral ribonucleoprotein (vRNP) complexes. These vRNP complexes carry out both viral transcription and replication within the nucleus of the host cell. The role of NP in viral transcription and replication, although essential, is not well understood. The findings presented in this thesis support a role for NP in the ...

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Lauren Turrell More by this author

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Supervisor
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Funding agency for:
Lauren Turrell
Type of award:
DPhil
Awarding institution:
University of Oxford

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