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Thesis

The synthesis and biological evaluation of novel N-acetylhexosaminidase inhibitors

Abstract:

Iminosugars are known to behave as carbohydrate mimics in biological systems by virtue of their similar structures. However as the ring nitrogen prevents metabolism it means that iminosugars have the potential to become inhibitors of these systems. It is known, for example, that iminosugars can behave as mimics in the hydrolysis mechanism. This leads to possible medicinal applications of iminosugars. One such case is lysosomal storage disorders which arise as a result of a genetic defect w...

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Role:
Supervisor
Role:
Supervisor
Institution:
University of Oxford
Oxford college:
Exeter College
Department:
Medical Sciences Division - Biochemistry
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:abe6fa1a-1922-45ee-b1f2-740247242129
Local pid:
ora:6580

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