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Glutamate acts as a key signal linking glucose metabolism to incretin/cAMP action to amplify insulin secretion.

Abstract:

Incretins, hormones released by the gut after meal ingestion, are essential for maintaining systemic glucose homeostasis by stimulating insulin secretion. The effect of incretins on insulin secretion occurs only at elevated glucose concentrations and is mediated by cAMP signaling, but the mechanism linking glucose metabolism and cAMP action in insulin secretion is unknown. We show here, using a metabolomics-based approach, that cytosolic glutamate derived from the malate-aspartate shuttle upo...

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Publication status:
Published

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Publisher:
Elsevier
Journal:
Cell reports More from this journal
Volume:
9
Issue:
2
Pages:
661-673
Publication date:
2014-10-01
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Language:
English
Pubs id:
pubs:490687
UUID:
uuid:abe5ec6a-9cb7-419e-ab49-2b02c2a26e9f
Local pid:
pubs:490687
Source identifiers:
490687
Deposit date:
2015-01-15

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