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Early- and subsequent- response of cognitive functioning in Alzheimer's disease: Individual-participant data from five pivotal randomized clinical trials of donepezil

Abstract:

The association between early improvement and subsequent change in cognition is unexamined in antidementia clinical trials. We aimed to examine the consequences of early-response to antidementia medication in Alzheimer's disease. Participant-level data were analyzed from five pivotal clinical trials of donepezil for Alzheimer's disease lasting up to 24 weeks (N = 1917). Early-response was based on Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) change scores under minus fou...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0002-5544-0420
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Role:
Author
ORCID:
0000-0002-4544-0910
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Role:
Author
ORCID:
0000-0003-4475-8043
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Role:
Author
ORCID:
0000-0002-6943-5091
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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
ORCID:
0000-0001-5179-8321
Publisher:
Elsevier
Journal:
Journal of Psychiatric Research More from this journal
Volume:
148
Pages:
159-164
Publication date:
2022-01-29
Acceptance date:
2022-01-26
DOI:
ISSN:
0022-3956
Language:
English
Keywords:
Pubs id:
1237184
Local pid:
pubs:1237184
Deposit date:
2022-02-07

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