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Spleen plays an important role in maintaining tolerance after removal of the vascularized heart graft.

Abstract:

BACKGROUND: This study addresses the question of the mechanism for maintaining tolerance to donor alloantigen in the absence of antigen and the role of secondary lymphoid tissues. METHODS: Depleting anti-CD4 antibody administration in conjunction with allogeneic heart transplantation generates donor-specific operational tolerance. Primary C57BL/6 heart grafts were transplanted into the neck cavity of the anti-CD4 antibody pretreated C3H/He mice. At day 50, functioning heart grafts were remov...

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Publication status:
Published

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Journal:
Transplantation
Volume:
83
Issue:
9
Pages:
1226-1233
Publication date:
2007-05-01
DOI:
EISSN:
1534-6080
ISSN:
0041-1337
Source identifiers:
136013

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