Journal article
Validating the ratio of insulin like growth factor binding protein 4 to sex hormone binding globulin as a prognostic predictor of preterm birth in Viet Nam: a case-cohort study
- Abstract:
-
Objective
To validate a serum biomarker developed in the USA for preterm birth (PTB) risk stratification in Viet Nam.Methods
Women with singleton pregnancies (n = 5000) were recruited between 19+0-23+6 weeks’ gestation at Tu Du Hospital, Ho Chi Minh City. Maternal serum was collected from 19+0-22+6 weeks’ gestation and participants followed to neonatal discharge. Relative insulin-like growth factor binding protein 4 (IGFBP4) and sex hormone binding globulin (SHBG) abundances were measured by mass spectrometry and their ratio compared between PTB cases and term controls. Discrimination (area under the receiver operating characteristic curve, AUC) and calibration for PTB <37 and <34 weeks’ gestation were tested, with model tuning using clinical factors. Measured outcomes included all PTBs (any birth ≤37 weeks’ gestation) and spontaneous PTBs (birth ≤37 weeks’ gestation with clinical signs of initiation of parturition).Results
Complete data were available for 4984 (99.7%) individuals. The cohort PTB rate was 6.7% (n = 335). We observed an inverse association between the IGFBP4/SHBG ratio and gestational age at birth (p = 0.017; AUC 0.60 [95% CI, 0.53-0.68]). Including previous PTB (for multiparous women) or prior miscarriage (for primiparous women) improved performance (AUC 0.65 and 0.70, respectively, for PTB <37 and <34 weeks’ gestation). Optimal performance (AUC 0.74) was seen within 19-20 weeks’ gestation, for BMI >21 kg/m2 and age 20-35 years.Conclusion
We have validated a novel serum biomarker for PTB risk stratification in a very different setting to the original study. Further research is required to determine appropriate ratio thresholds based on the prevalence of risk factors and the availability of resources and preventative therapies.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 2.4MB, Terms of use)
-
- Publisher copy:
- 10.1080/14767058.2024.2333923
Authors
- Publisher:
- Taylor and Francis
- Journal:
- Journal of Maternal-Fetal and Neonatal Medicine More from this journal
- Volume:
- 37
- Issue:
- 1
- Article number:
- 2333923
- Place of publication:
- England
- Publication date:
- 2024-04-07
- Acceptance date:
- 2024-03-13
- DOI:
- EISSN:
-
1476-4954
- ISSN:
-
1476-7058
- Pmid:
-
38584143
- Language:
-
English
- Keywords:
- Pubs id:
-
1989587
- Local pid:
-
pubs:1989587
- Deposit date:
-
2024-07-16
Terms of use
- Copyright holder:
- Hirst et al
- Copyright date:
- 2024
- Rights statement:
- © 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record