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Costimulation and endogenous MHC ligands contribute to T cell recognition.

Abstract:

To initiate an immune response, key receptor-ligand pairs must cluster in "immune synapses" at the T cell-antigen-presenting cell (APC) interface. We visualized the accumulation of a major histocompatibility complex (MHC) class II molecule, I-E(k), at a T cell-B cell interface and found it was dependent on both antigen recognition and costimulation. This suggests that costimulation-driven active transport of T cell surface molecules helps to drive immunological synapse formation. Although onl...

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Publisher copy:
10.1038/ni741

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Nature immunology More from this journal
Volume:
3
Issue:
1
Pages:
42-47
Publication date:
2002-01-01
DOI:
EISSN:
1529-2916
ISSN:
1529-2908

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