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Journal article

Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer.

Abstract:

Human colorectal cancer cell lines are used widely to investigate tumor biology, experimental therapy, and biomarkers. However, to what extent these established cell lines represent and maintain the genetic diversity of primary cancers is uncertain. In this study, we profiled 70 colorectal cancer cell lines for mutations and DNA copy number by whole-exome sequencing and SNP microarray analyses, respectively. Gene expression was defined using RNA-Seq. Cell line data were compared with those pu...

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Publication status:
Published

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Journal:
Cancer research
Volume:
74
Issue:
12
Pages:
3238-3247
Publication date:
2014-06-01
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
Source identifiers:
466101
Language:
English
Keywords:
Pubs id:
pubs:466101
UUID:
uuid:abd8ab82-0da7-4262-b690-0eff171e7a1a
Local pid:
pubs:466101
Deposit date:
2014-09-27

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