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Invertebrate models of spinal muscular atrophy: insights into mechanisms and potential therapeutics.

Abstract:

Invertebrate genetic models with their tractable neuromuscular systems are effective vehicles for the study of human nerve and muscle disorders. This is exemplified by insights made into spinal muscular atrophy (SMA) using the fruit fly Drosophila melanogaster and the nematode worm Caenorhabditis elegans. For speed and economy, these invertebrates offer convenient, whole-organism platforms for genetic screening as well as RNA interference (RNAi) and chemical library screens, permitting the ra...

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Publication status:
Published

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Publisher copy:
10.1002/bies.201100082
Journal:
BioEssays : news and reviews in molecular, cellular and developmental biology More from this journal
Volume:
33
Issue:
12
Pages:
956-965
Publication date:
2011-12-01
DOI:
EISSN:
1521-1878
ISSN:
0265-9247
Language:
English
Keywords:
Pubs id:
pubs:216360
UUID:
uuid:abc93232-3acc-463e-8e47-83cb02ef94b6
Local pid:
pubs:216360
Source identifiers:
216360
Deposit date:
2012-12-19

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