- Abstract:
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Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power to discover risk loci. Here we perform a meta-analysis of these GWAS, add a new GWAS and perform replication analyses resulting in 9,866 cases and 239,188 controls. We confirm all nine known risk loci and discover eight new loci at 6p22.3 (rs34229995, P=1.31 × 10(-8)), 6q21 (...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 886.0kb)
-
- Publisher copy:
- 10.1038/ncomms12050
-
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- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 7
- Pages:
- 12050
- Publication date:
- 2016-07-05
- Acceptance date:
- 2016-05-24
- DOI:
- EISSN:
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2041-1723
- ISSN:
-
2041-1723
- Pubs id:
-
pubs:737691
- URN:
-
uri:abc3df5f-006c-49bc-bf27-ba1aee627260
- UUID:
-
uuid:abc3df5f-006c-49bc-bf27-ba1aee627260
- Local pid:
- pubs:737691
- Language:
- English
- Keywords:
- Copyright holder:
- Migliorini et al
- Copyright date:
- 2016
- Notes:
- © The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Journal article
Genome-wide association study identifies multiple susceptibility loci for multiple myeloma.
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Myeloma UK
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Bloodwise
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Cancer Research UK
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