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Genome-wide association study identifies multiple susceptibility loci for multiple myeloma.

Abstract:

Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power to discover risk loci. Here we perform a meta-analysis of these GWAS, add a new GWAS and perform replication analyses resulting in 9,866 cases and 239,188 controls. We confirm all nine known risk loci and discover eight new loci at 6p22.3 (rs34229995, P=1.31 × 10(-8)), 6q21 (...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ncomms12050

Authors


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Name:
Medical Research Council
Grant:
MC_PC_15018
More from this funder
Name:
National Institutes of Health
Grant:
P01 CA055819
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Name:
Swedish Society of Medicine
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Name:
Siv-Inger and Per-Erik Andersson Foundation
Publisher:
Nature Publishing Group
Journal:
Nature Communications More from this journal
Volume:
7
Pages:
12050
Publication date:
2016-07-01
Acceptance date:
2016-05-24
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Pmid:
27363682
Language:
English
Keywords:
Pubs id:
pubs:737691
UUID:
uuid:abc3df5f-006c-49bc-bf27-ba1aee627260
Local pid:
pubs:737691
Source identifiers:
737691
Deposit date:
2017-12-20

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