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Genome-wide association study identifies multiple susceptibility loci for multiple myeloma.

Abstract:

Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power to discover risk loci. Here we perform a meta-analysis of these GWAS, add a new GWAS and perform replication analyses resulting in 9,866 cases and 239,188 controls. We confirm all nine known risk loci and discover eight new loci at 6p22.3 (rs34229995, P=1.31 × 10(-8)), 6q21 (...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/ncomms12050

Authors


Mitchell, JS More by this author
Weinhold, N More by this author
Försti, A More by this author
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Cancer Research UK More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
7
Pages:
12050
Publication date:
2016-07-05
Acceptance date:
2016-05-24
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Pubs id:
pubs:737691
URN:
uri:abc3df5f-006c-49bc-bf27-ba1aee627260
UUID:
uuid:abc3df5f-006c-49bc-bf27-ba1aee627260
Local pid:
pubs:737691
Language:
English
Keywords:

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