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Ischaemia-reperfusion injury impairs tissue plasminogen activator release in man.

Abstract:

AIMS: Ischaemia-reperfusion (IR) injury causes endothelium-dependent vasomotor dysfunction that can be prevented by ischaemic preconditioning. The effects of IR injury and preconditioning on endothelium-dependent tissue plasminogen activator (t-PA) release, an important mediator of endogenous fibrinolysis, remain unknown. METHODS AND RESULTS: Ischaemia-reperfusion injury (limb occlusion at 200 mmHg for 20 min) was induced in 22 healthy subjects. In 12 subjects, IR injury was preceded by local...

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Publication status:
Published

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Publisher copy:
10.1093/eurheartj/ehr380

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
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Journal:
European heart journal
Volume:
33
Issue:
15
Pages:
1920-1927
Publication date:
2012-08-01
DOI:
EISSN:
1522-9645
ISSN:
0195-668X
Source identifiers:
186657

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