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Safety and efficacy of dihydroartemisinin-piperaquine in falciparum malaria: a prospective multi-centre individual patient data analysis.

Abstract:

BACKGROUND: The fixed dose antimalarial combination of dihydroartemisinin-piperaquine (DP) is a promising new artemisinin-based combination therapy (ACT). We present an individual patient data analysis of efficacy and tolerability in acute uncomplicated falciparum malaria, from seven published randomized clinical trials conducted in Africa and South East Asia using a predefined in-vivo protocol. Comparator drugs were mefloquine-artesunate (MAS3) in Thailand, Myanmar, Laos and Cambodia; artem...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0006358

Authors


More from this funder
Name:
Holley-Pharm
Funding agency for:
Nosten, F
More from this funder
Name:
Medicines for Malaria Venture
Funding agency for:
Nosten, F
Publisher:
Public Library of Science
Journal:
PloS one More from this journal
Volume:
4
Issue:
7
Article number:
e6358
Publication date:
2009-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Language:
English
Keywords:
UUID:
uuid:abbae30a-c0bd-43ec-acb6-37737e2c37da
Local pid:
pubs:34815
Source identifiers:
34815
Deposit date:
2012-12-19

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