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Protocols to demonstrate slowing of Alzheimer disease progression. Position paper from the International Working Group on Harmonization of Dementia Drug Guidelines. The Disease Progression Sub-Group.

Abstract:

Two suggested clinical trial designs for assessing progression of Alzheimer disease are the randomized withdrawal design and the randomized start design. The most promising of these, the randomized start design, has the potential to demonstrate a delay in progression, but there remain problematic design, ethical, and statistical issues to be solved before the protocol can be used in a clinical trial. The development of biological markers of the disease process using neuroimaging or other meas...

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Authors


Forette, F More by this author
Harvey, RJ More by this author
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Journal:
Alzheimer disease and associated disorders
Volume:
11 Suppl 3
Pages:
50-53
Publication date:
1997
EISSN:
1546-4156
ISSN:
0893-0341
URN:
uuid:abb8d0fc-948b-4144-8925-cd617de73d2a
Source identifiers:
60857
Local pid:
pubs:60857

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