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Journal article

Protocols to demonstrate slowing of Alzheimer disease progression. Position paper from the International Working Group on Harmonization of Dementia Drug Guidelines. The Disease Progression Sub-Group.

Abstract:

Two suggested clinical trial designs for assessing progression of Alzheimer disease are the randomized withdrawal design and the randomized start design. The most promising of these, the randomized start design, has the potential to demonstrate a delay in progression, but there remain problematic design, ethical, and statistical issues to be solved before the protocol can be used in a clinical trial. The development of biological markers of the disease process using neuroimaging or other meas...

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Journal:
Alzheimer disease and associated disorders
Volume:
11 Suppl 3
Pages:
50-53
Publication date:
1997-01-01
EISSN:
1546-4156
ISSN:
0893-0341
Source identifiers:
60857
Language:
English
Keywords:
Pubs id:
pubs:60857
UUID:
uuid:abb8d0fc-948b-4144-8925-cd617de73d2a
Local pid:
pubs:60857
Deposit date:
2012-12-19

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