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T cell depletion by exposure to Campath-1G in vitro prevents graft-versus-host disease.

Abstract:

Campath-1G is an immunosuppressive monoclonal antibody directed against human lymphocytes. Its effectiveness in preventing graft-versus-host disease (GVHD) by simple opsonisation of bone marrow T-cells has been studied in 36 consecutive allografts: in 17 for leukaemia, one for essential thrombocytosis and four for myeloma this was the sole means of GVHD prophylaxis. A further eight patients with aplastic anaemia received 3 months post-transplantation cyclosporin A (CsA) for this purpose where...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Bone marrow transplantation
Volume:
13
Issue:
6
Pages:
763-769
Publication date:
1994-06-01
EISSN:
1476-5365
ISSN:
0268-3369
Source identifiers:
21934

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