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One-pot, three-component sulfonimidamide synthesis exploiting the sulfinylamine reagent N -sulfinyltritylamine, TrNSO

Abstract:

Sulfonimidamides are increasingly important molecules in medicinal chemistry and agrochemistry, but their preparation requires lengthy synthetic sequences, which has likely limited their use. We describe a one-pot de novo synthesis of sulfonimidamides from widely available organometallic reagents and amines. This convenient and efficient process uses a stable sulfinylamine reagent, N-sulfinyltritylamine (TrNSO), available in one step on 10 gram scale, as a linchpin. In contrast to classical a...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/ange.201708590

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More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Oxford college:
Lincoln College
Role:
Author
ORCID:
0000-0002-0636-6471
Publisher:
Wiley Publisher's website
Journal:
Angewandte Chemie Journal website
Volume:
129
Issue:
47
Pages:
15133-15137
Publication date:
2017-09-19
DOI:
EISSN:
1521-3757
ISSN:
0044-8249
Source identifiers:
737369
Keywords:
Pubs id:
pubs:737369
UUID:
uuid:abb32183-40f7-4bc8-9bb0-857791d49d99
Local pid:
pubs:737369
Deposit date:
2018-08-30

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