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The role of the membrane in the structure and biophysical robustness of the dengue virion envelope

Abstract:

The dengue virion is surrounded by an envelope of membrane proteins surrounding a lipid bilayer. We have combined the cryoelectron microscopy structures of the membrane proteins (PDB: 3J27) with a lipid bilayer whose composition is based on lipidomics data for insect cell membranes, to obtain a near-atomic resolution computational model of the envelope of the dengue virion. A coarse-grained molecular dynamics simulation on the microsecond timescale enables analysis of key biophysical properti...

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Publication status:
In press
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.str.2015.12.011

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
Wellcome Trust More from this funder
EPA Cephalosporin Fund More from this funder
Engineering and Physical Sciences Research Council More from this funder
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Publisher:
Cell Press Publisher's website
Journal:
Structure Journal website
Publication date:
2016-01-01
DOI:
ISSN:
1878-4186
URN:
uuid:abb26797-52e5-4aa7-8534-94c11d2c7a1b
Source identifiers:
580637
Local pid:
pubs:580637

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