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Risedronate does not reduce mechanical loading-related increases in cortical and trabecular bone mass in mice.

Abstract:

To establish whether the combination of anti-resorptive therapy with mechanical loading has a negative, additive or synergistic effect on bone structure, we assessed the separate and combined effects of risedronate and non-invasive dynamic loading on trabecular and cortical bone. Seventeen-week-old female C57BL/6 mice were given daily subcutaneous injections of vehicle (n=20) or risedronate at a dose of 0.15, 1.5, 15 or 150 μg/kg/day (n=10 in each) for 17 days. From the fourth day of treatmen...

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Publication status:
Published

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Publisher copy:
10.1016/j.bone.2011.03.775

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Journal:
Bone
Volume:
49
Issue:
1
Pages:
133-139
Publication date:
2011-07-05
DOI:
EISSN:
1873-2763
ISSN:
8756-3282
URN:
uuid:abaf98a3-e9d9-4355-a36e-2f8cfb7ec368
Source identifiers:
149737
Local pid:
pubs:149737

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