- Abstract:
-
To establish whether the combination of anti-resorptive therapy with mechanical loading has a negative, additive or synergistic effect on bone structure, we assessed the separate and combined effects of risedronate and non-invasive dynamic loading on trabecular and cortical bone. Seventeen-week-old female C57BL/6 mice were given daily subcutaneous injections of vehicle (n=20) or risedronate at a dose of 0.15, 1.5, 15 or 150 μg/kg/day (n=10 in each) for 17 days. From the fourth day of treatmen...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.bone.2011.03.775
-
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- Journal:
- Bone
- Volume:
- 49
- Issue:
- 1
- Pages:
- 133-139
- Publication date:
- 2011-07-05
- DOI:
- EISSN:
-
1873-2763
- ISSN:
-
8756-3282
- URN:
-
uuid:abaf98a3-e9d9-4355-a36e-2f8cfb7ec368
- Source identifiers:
-
149737
- Local pid:
- pubs:149737
- Language:
- English
- Keywords:
- Copyright date:
- 2011
Journal article
Risedronate does not reduce mechanical loading-related increases in cortical and trabecular bone mass in mice.
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