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Combinatorial drug screening identifies Ewing sarcoma-specific sensitivities

Abstract:

Improvements in survival for Ewing sarcoma pediatric and adolescent patients have been modest over the past 20 years. Combinations of anticancer agents endure as an option to overcome resistance to single treatments caused by compensatory pathways. Moreover, combinations are thought to lessen any associated adverse side effects through reduced dosing, which is particularly important in childhood tumors. Using a parallel phenotypic combinatorial screening approach of cells derived from three p...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1158/1535-7163.MCT-16-0235

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
More from this funder
Name:
FWF ERA-Net
Funding agency for:
Mutz, C
Grant:
I1225-B19
More from this funder
Name:
European Union Seventh Framework Programme
Funding agency for:
Radic-Sarikas, B
Tsafou, K
Emdal, K
Papamarkou, T
Huber, K
Olsen, J
Brunak, S
Kovar, H
Superti-Furga, G
Grant:
FP7- HEALTH-2010-259348-2
FP7- HEALTH-2010-259348-2
FP7- HEALTH-2010-259348-2
FP7- HEALTH-2010-259348-2
FP7- HEALTH-2010-259348-2
FP7- HEALTH-2010-259348-2
FP7- HEALTH-2010-259348-2
FP7- HEALTH-2010-259348-2
FP7- HEALTH-2010-259348-2
More from this funder
Name:
Austrian Academy of Sciences
Funding agency for:
Bennett, K
Publisher:
American Association for Cancer Research
Journal:
Molecular Cancer Therapeutics More from this journal
Volume:
16
Issue:
1
Pages:
88-101
Publication date:
2016-11-15
Acceptance date:
2016-11-03
DOI:
EISSN:
1538-8514
ISSN:
1535-7163
Language:
English
Keywords:
Pubs id:
pubs:668637
UUID:
uuid:ab9f1973-2f26-41ce-850a-8c74fc4be6bf
Local pid:
pubs:668637
Source identifiers:
668637
Deposit date:
2017-01-13

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