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Cytomegalovirus (CMV) epitope-specific CD4(+) T cells are inflated in HIV(+) CMV(+) subjects

Abstract:

Select CMV epitopes drive life-long CD8(+) T cell memory inflation, but the extent of CD4 memory inflation is poorly studied. CD4(+) T cells specific for human CMV (HCMV) are elevated in HIV(+) HCMV(+) subjects. To determine whether HCMV epitope-specific CD4(+) T cell memory inflation occurs during HIV infection, we used HLA-DR7 (DRB1*07:01) tetramers loaded with the glycoprotein B DYSNTHSTRYV (DYS) epitope to characterize circulating CD4(+) T cells in coinfected HLA-DR7(+) long-term nonprogr...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.4049/jimmunol.1700851

Authors


Pilkinton, MA More by this author
Gaudieri, S More by this author
McDonnell, WJ More by this author
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Grant:
P30 AI110527 (to S.A.M.), P01 AI030731 and R01 AI094019 (to D.M.K.), P50 GM115305 (to E.J.P.), T32 AI007474 (to S.A.K.), P01 AI030731 (to Lawrence Corey, principal investigator), UL1 TR000445 (to Gordon Bernard, principal investigator), HHSN272201300006C (to the NIH Tetramer Core Facility)
Publisher:
American Association of Immunologists Publisher's website
Journal:
Journal of Immunology Journal website
Volume:
199
Issue:
9
Pages:
3187-3201
Publication date:
2017-10-23
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Pubs id:
pubs:732938
URN:
uri:ab9a1b04-dfcf-43a7-8da9-ae3f23a98fba
UUID:
uuid:ab9a1b04-dfcf-43a7-8da9-ae3f23a98fba
Local pid:
pubs:732938
Language:
English

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