- Abstract:
-
Select CMV epitopes drive life-long CD8(+) T cell memory inflation, but the extent of CD4 memory inflation is poorly studied. CD4(+) T cells specific for human CMV (HCMV) are elevated in HIV(+) HCMV(+) subjects. To determine whether HCMV epitope-specific CD4(+) T cell memory inflation occurs during HIV infection, we used HLA-DR7 (DRB1*07:01) tetramers loaded with the glycoprotein B DYSNTHSTRYV (DYS) epitope to characterize circulating CD4(+) T cells in coinfected HLA-DR7(+) long-term nonprogr...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Publisher copy:
- 10.4049/jimmunol.1700851
-
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- Grant:
- P30 AI110527 (to S.A.M.), P01 AI030731 and R01 AI094019 (to D.M.K.), P50 GM115305 (to E.J.P.), T32 AI007474 (to S.A.K.), P01 AI030731 (to Lawrence Corey, principal investigator), UL1 TR000445 (to Gordon Bernard, principal investigator), HHSN272201300006C (to the NIH Tetramer Core Facility)
- Grant:
- T32 GM007347 (to C.O.A.)
- Publisher:
- American Association of Immunologists Publisher's website
- Journal:
- Journal of Immunology Journal website
- Volume:
- 199
- Issue:
- 9
- Pages:
- 3187-3201
- Publication date:
- 2017-10-23
- DOI:
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- Pubs id:
-
pubs:732938
- URN:
-
uri:ab9a1b04-dfcf-43a7-8da9-ae3f23a98fba
- UUID:
-
uuid:ab9a1b04-dfcf-43a7-8da9-ae3f23a98fba
- Local pid:
- pubs:732938
- Language:
- English
- Copyright holder:
- American Association of Immunologists, Inc
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 by The American Association of Immunologists, Inc.
Journal article
Cytomegalovirus (CMV) epitope-specific CD4(+) T cells are inflated in HIV(+) CMV(+) subjects
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