Journal article
Cytomegalovirus (CMV) epitope-specific CD4(+) T cells are inflated in HIV(+) CMV(+) subjects
- Abstract:
-
Select CMV epitopes drive life-long CD8(+) T cell memory inflation, but the extent of CD4 memory inflation is poorly studied. CD4(+) T cells specific for human CMV (HCMV) are elevated in HIV(+) HCMV(+) subjects. To determine whether HCMV epitope-specific CD4(+) T cell memory inflation occurs during HIV infection, we used HLA-DR7 (DRB1*07:01) tetramers loaded with the glycoprotein B DYSNTHSTRYV (DYS) epitope to characterize circulating CD4(+) T cells in coinfected HLA-DR7(+) long-term nonprogr...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.4049/jimmunol.1700851
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Authors
Funding
+ National Institutes of Health
More from this funder
Grant:
P30 AI110527
(to S.A.M.), P01 AI030731 and R01 AI094019 (to D.M.K.), P50 GM115305
(to E.J.P.), T32 AI007474 (to S.A.K.), P01 AI030731 (to Lawrence Corey, principal
investigator), UL1 TR000445 (to Gordon Bernard, principal investigator),
HHSN272201300006C (to the NIH Tetramer Core Facility)
+ National
Institute of General Medical Sciences
More from this funder
Grant:
T32 GM007347 (to C.O.A.)
Bibliographic Details
- Publisher:
- American Association of Immunologists Publisher's website
- Journal:
- Journal of Immunology Journal website
- Volume:
- 199
- Issue:
- 9
- Pages:
- 3187-3201
- Publication date:
- 2017-10-23
- DOI:
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- Pubs id:
-
pubs:732938
- URN:
-
uri:ab9a1b04-dfcf-43a7-8da9-ae3f23a98fba
- UUID:
-
uuid:ab9a1b04-dfcf-43a7-8da9-ae3f23a98fba
- Local pid:
- pubs:732938
- Paper number:
- 9
Item Description
- Language:
- English
Terms of use
- Copyright holder:
- American Association of Immunologists, Inc
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 by The American Association of Immunologists, Inc.
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