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Journal article

Evidence of cis-acting regulatory variation in PTPN22 in patients with rheumatoid arthritis.

Abstract:

OBJECTIVES: To assess whether there are cis-regulatory polymorphisms that regulate protein tyrosine phosphatase, non-receptor type 22 (PTPN22) expression in rheumatoid arthritis (RA). METHODS: RNA was extracted from positively selected CD56+, CD8+, and CD4+ mononuclear cells and the 'residual' cells from 12 RA patients heterozygous for the PTPN22 C1858T single nucleotide polymorphism (SNP) (rs2476601). Relative allelic expression was measured by single base extension (SBE) assay. RESULTS: Th...

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Scandinavian journal of rheumatology More from this journal
Volume:
41
Issue:
4
Pages:
249-252
Publication date:
2012-08-01
DOI:
EISSN:
1502-7732
ISSN:
0300-9742
Language:
English
Keywords:
Pubs id:
pubs:333062
UUID:
uuid:ab951f7e-6db5-4503-92ac-42f28483b51d
Local pid:
pubs:333062
Source identifiers:
333062
Deposit date:
2013-11-16

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