- Abstract:
-
AIMS: In vitro studies have shown impairment of energy metabolism in cardiac fibroblasts from Fabry patients. A recent in vivo study reported an association between cardiac energy metabolism and increased myocardial mass in Fabry patients. We therefore assessed possible disturbances of cardiac energy metabolism in Fabry patients by in vivo (31)P-MR-spectroscopy. Additionally, the effect of enzyme replacement therapy (ERT) on cardiac energetics was tested. METHODS AND RESULTS: Twenty-three pa...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1093/eurjhf/hfq211
-
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- Journal:
- European journal of heart failure
- Volume:
- 13
- Issue:
- 3
- Pages:
- 278-283
- Publication date:
- 2011-03-05
- DOI:
- EISSN:
-
1879-0844
- ISSN:
-
1388-9842
- URN:
-
uuid:ab8be4d7-91b5-45b0-95ae-bb5db369b1b0
- Source identifiers:
-
124879
- Local pid:
- pubs:124879
- Copyright date:
- 2011
Journal article
Cardiac energy metabolism is disturbed in Fabry disease and improves with enzyme replacement therapy using recombinant human galactosidase A.
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