Thesis icon

Thesis

Transcriptional regulation of endothelial KLF2 in vascular development

Abstract:

The development of a functional vascular system is critically dependent on shear stress, a hemodynamic force exerted onto the vascular endothelium by flowing blood. Krüppel-like factor 2 (KLF2) is the central transcriptional regulator of the endothelial shear stress response, yet the mechanisms by which shear stress signalling controls KLF2 expression remain controversial. Activation of KLF2 by shear stress was previously hypothesised to occur through a MEK5-ERK5-MEF2 pathway directly interac...

Expand abstract

Actions


Authors


More by this author
Division:
MSD
Department:
Doctoral Training Centre - MSD
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Sub department:
Physiology Anatomy & Genetics
Research group:
Institute of developmental and regenerative medicine
Role:
Supervisor
ORCID:
0000-0002-2566-2348
Division:
MSD
Department:
Doctoral Training Centre - MSD
Role:
Supervisor
More from this funder
Name:
British Heart Foundation
Funder identifier:
http://dx.doi.org/10.13039/501100000274
Programme:
BHF 4-year DPhil Cardiovascular Science
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP