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Journal article

Non-transferrin-bound iron (NTBI) uptake by T lymphocytes: evidence for the selective acquisition of oligomeric ferric citrate species.

Abstract:

Abstract Iron is an essential nutrient in several biological processes such as oxygen transport, DNA replication and erythropoiesis. Plasma iron normally circulates bound to transferrin. In iron overload disorders, however, iron concentrations exceed transferrin binding capacity and iron appears complexed with low molecular weight molecules, known as non-transferrin-bound iron (NTBI). NTBI is responsible for the toxicity associated with iron-overload pathologies but the mechanisms leading to ...

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Publication status:
Published

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
RDM - Investigative Medicine Division
Role:
Author
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Contributors

Role:
Editor
Department:
Basic and Clinical Research on Iron Biology, IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.
Journal:
PloS one
Issue:
11
Publication date:
2013-01-02
Acceptance date:
2013-09-27
DOI:
ISSN:
1932-6203
Pubs id:
pubs:562462
URN:
uri:ab7eaf78-4bb3-41f4-b7bd-f6d67c3bc363
UUID:
uuid:ab7eaf78-4bb3-41f4-b7bd-f6d67c3bc363
Local pid:
pubs:562462

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