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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease.

Abstract:

A locus segregating with familial Alzheimer's disease (AD) has been mapped to chromosome 21, close to the amyloid precursor protein (APP) gene. Recombinants between the APP gene and the AD locus have been reported which seemed to exclude it as the site of the mutation causing familial AD. But recent genetic analysis of a large number of AD families has demonstrated that the disease is heterogeneous. Families with late-onset AD do not show linkage to chromosome 21 markers. Some families with e...

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Publication status:
Published

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Publisher copy:
10.1038/349704a0

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Journal:
Nature
Volume:
349
Issue:
6311
Pages:
704-706
Publication date:
1991-02-01
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Source identifiers:
440041

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