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Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2).

Abstract:

"Regulator of G-protein signaling" (RGS) proteins facilitate the termination of G protein-coupled receptor (GPCR) signaling via their ability to increase the intrinsic GTP hydrolysis rate of Galpha subunits (known as GTPase-accelerating protein or "GAP" activity). RGS2 is unique in its in vitro potency and selectivity as a GAP for Galpha(q) subunits. As many vasoconstrictive hormones signal via G(q) heterotrimer-coupled receptors, it is perhaps not surprising that RGS2-deficient mice exhibit ...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m109.024711

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Journal:
Journal of biological chemistry
Volume:
284
Issue:
29
Pages:
19402-19411
Publication date:
2009-07-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
41299

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