- Abstract:
-
"Regulator of G-protein signaling" (RGS) proteins facilitate the termination of G protein-coupled receptor (GPCR) signaling via their ability to increase the intrinsic GTP hydrolysis rate of Galpha subunits (known as GTPase-accelerating protein or "GAP" activity). RGS2 is unique in its in vitro potency and selectivity as a GAP for Galpha(q) subunits. As many vasoconstrictive hormones signal via G(q) heterotrimer-coupled receptors, it is perhaps not surprising that RGS2-deficient mice exhibit ...
Expand abstract - Publication status:
- Published
- Journal:
- The Journal of biological chemistry
- Volume:
- 284
- Issue:
- 29
- Pages:
- 19402-19411
- Publication date:
- 2009-07-05
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- URN:
-
uuid:ab7472ba-803c-4f4f-9356-6f55a4a14e6b
- Source identifiers:
-
41299
- Local pid:
- pubs:41299
- Language:
- English
- Keywords:
- Copyright date:
- 2009
Journal article
Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2).
Actions
Authors
Bibliographic Details
Item Description
Terms of use
Metrics
Altmetrics
Dimensions
If you are the owner of this record, you can report an update to it here: Report update to this record