"Regulator of G-protein signaling" (RGS) proteins facilitate the termination of G protein-coupled receptor (GPCR) signaling via their ability to increase the intrinsic GTP hydrolysis rate of Galpha subunits (known as GTPase-accelerating protein or "GAP" activity). RGS2 is unique in its in vitro potency and selectivity as a GAP for Galpha(q) subunits. As many vasoconstrictive hormones signal via G(q) heterotrimer-coupled receptors, it is perhaps not surprising that RGS2-deficient mice exhibit ...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2).
If you are the owner of this record, you can report an update to it here: Report update to this record