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Journal article

Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2).

Abstract:

"Regulator of G-protein signaling" (RGS) proteins facilitate the termination of G protein-coupled receptor (GPCR) signaling via their ability to increase the intrinsic GTP hydrolysis rate of Galpha subunits (known as GTPase-accelerating protein or "GAP" activity). RGS2 is unique in its in vitro potency and selectivity as a GAP for Galpha(q) subunits. As many vasoconstrictive hormones signal via G(q) heterotrimer-coupled receptors, it is perhaps not surprising that RGS2-deficient mice exhibit ...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m109.024711

Authors


Kimple, AJ More by this author
Soundararajan, M More by this author
Hutsell, SQ More by this author
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Journal:
The Journal of biological chemistry
Volume:
284
Issue:
29
Pages:
19402-19411
Publication date:
2009-07-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:ab7472ba-803c-4f4f-9356-6f55a4a14e6b
Source identifiers:
41299
Local pid:
pubs:41299

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