- Abstract:
-
Microbeam radiation therapy (MRT) using high doses of synchrotron X-rays can destroy tumours in animal models whilst causing little damage to normal tissues. Determining the spatial distribution of radiation doses delivered during MRT at a microscopic scale is a major challenge. Film and semiconductor dosimetry as well as Monte Carlo methods struggle to provide accurate estimates of dose profiles and peak-to-valley dose ratios at the position of the targeted and traversed tissues whose biolog...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
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(pdf, 304.6KB)
-
- Publisher copy:
- 10.1371/journal.pone.0029853
-
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- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PloS one Journal website
- Volume:
- 7
- Issue:
- 1
- Pages:
- e29853
- Chapter number:
- ARTN e29853
- Publication date:
- 2012-01-06
- DOI:
- EISSN:
-
1932-6203
- ISSN:
-
1932-6203
- URN:
-
uuid:ab73835f-de24-44b8-9516-43147f1a0c4d
- Source identifiers:
-
237044
- Local pid:
- pubs:237044
- Copyright holder:
- Rothkamm et al.
- Copyright date:
- 2012
- Notes:
- Copyright 2012 Rothkamm et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal article
In situ biological dose mapping estimates the radiation burden delivered to 'spared' tissue between synchrotron X-ray microbeam radiotherapy tracks.
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Australian Nuclear Science and Technology Organisation
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Cancer Council Victoria
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National Health and Medical Research Council
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Cancer Research UK
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NIHR Centre for Research in Health Protection at the Health Protection Agency
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