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In situ biological dose mapping estimates the radiation burden delivered to 'spared' tissue between synchrotron X-ray microbeam radiotherapy tracks.

Abstract:

Microbeam radiation therapy (MRT) using high doses of synchrotron X-rays can destroy tumours in animal models whilst causing little damage to normal tissues. Determining the spatial distribution of radiation doses delivered during MRT at a microscopic scale is a major challenge. Film and semiconductor dosimetry as well as Monte Carlo methods struggle to provide accurate estimates of dose profiles and peak-to-valley dose ratios at the position of the targeted and traversed tissues whose biolog...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0029853

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Institution:
University of Oxford
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Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology, CRUK/MRC Ox Inst for Radiation Oncology
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Author
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Australian Nuclear Science and Technology Organisation More from this funder
Cancer Council Victoria More from this funder
National Health and Medical Research Council More from this funder
Cancer Research UK More from this funder
NIHR Centre for Research in Health Protection at the Health Protection Agency More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
7
Issue:
1
Pages:
e29853
Chapter number:
ARTN e29853
Publication date:
2012-01-06
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:ab73835f-de24-44b8-9516-43147f1a0c4d
Source identifiers:
237044
Local pid:
pubs:237044

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