Mechanisms of Peripheral Tolerance and Suppression Induced by Monoclonal Antibodies to CD4 and CD8

Journal article

Over the last five years it has become increasingly clear that the peripheral immune system can maintain tolerance to both self and non-self antigens through a variety of mechanisms. Although clonal deletion may play an important part in limiting rapidly expanding responses, there are many examples where antigen reactive T cells remain. It has been proposed that tolerance is maintained in this situation either by the induction of anergy or by ongoing suppression. The phenomenon known as immun...

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Authors: Cobbold, S; Adams, E; Marshall, SE; Davies, J; Waldmann, H

• Journal: Immunological Reviews
• Issue: 149
• Publication date: 1996-01-01
• ISSN: 0105-2896
• Language: English