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Loading of MHC class I and II presentation pathways by exogenous antigens: a quantitative in vivo comparison.

Abstract:

The MHC class I pathway is usually fueled by endogenous Ags, while exogenous Ags reach the MHC class II pathway. Although exogenous epitopes may also enter the MHC class I pathway, quantification of the efficiency of the process has remained a difficult task. In an attempt of such a quantification, we directly compared the amount of exogenous virus-like particles required for induction of cytotoxic T cell responses by cross-priming with the amount of virus-like particles required for inductio...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
Journal:
Journal of Immunology
Volume:
172
Issue:
10
Pages:
6129-6135
Publication date:
2004-05-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
469738

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