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Journal article

Enhanced efficacy in drug-resistant cancer cells through synergistic nanoparticle mediated delivery of cisplatin and decitabine

Abstract:

There are several limitations with monodrug cancer therapy, including poor bioavailability, rapid clearance and drug resistance. Combination therapy addresses these by exploiting synergism between different drugs against cancer cells. In particular, the combination of epigenetic therapies with conventional chemotherapeutic agents can improve the initial tumour response and overcome acquired drug resistance. Co-encapsulation of multiple therapeutic agents into a single polymeric nanoparticle i...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1039/c9na00684b

Authors


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Role:
Author
ORCID:
0000-0002-4930-7308
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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Sub department:
Institute of Biomedical Engineering
Role:
Author
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Division:
MSD
Department:
NDORMS
Sub department:
Botnar Research Centre
Role:
Author
ORCID:
0000-0003-3371-5929
Publisher:
Royal Society of Chemistry (RSC)
Journal:
Nanoscale Advances More from this journal
Volume:
2
Issue:
3
Pages:
1177-1186
Publication date:
2020-01-27
Acceptance date:
2020-01-26
DOI:
EISSN:
2516-0230
Language:
English
Pubs id:
1087301
Local pid:
pubs:1087301
Deposit date:
2020-02-13

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