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Structural basis for ligand-mediated mouse GITR activation.

Abstract:

Glucocorticoid-induced TNF receptor ligand (GITRL) is a member of the TNF super family (TNFSF). GITRL plays an important role in controlling regulatory T cells. The crystal structure of the mouse GITRL (mGITRL) was determined to 1.8-A resolution. Contrary to the current paradigm that all ligands in the TNFSF are trimeric, mGITRL associates as dimer through a unique C terminus tethering arm. Analytical ultracentrifuge studies revealed that in solution, the recombinant mGITRL exists as monomers...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0711206105

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Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
105
Issue:
2
Pages:
641-645
Publication date:
2008-01-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424

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