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Journal article

SpyAvidin hubs enable precise and ultrastable orthogonal nanoassembly.

Abstract:

The capture of biotin by streptavidin is an inspiration for supramolecular chemistry and a central tool for biological chemistry and nanotechnology, because of the rapid and exceptionally stable interaction. However, there is no robust orthogonal interaction to this hub, limiting the size and complexity of molecular assemblies that can be created. Here we combined traptavidin (a streptavidin variant maximizing biotin binding strength) with an orthogonal irreversible interaction. SpyTag is a p...

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Publication status:
Published

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Publisher copy:
10.1021/ja505584f

Authors


Publisher:
American Chemical Society
Journal:
Journal of the American Chemical Society More from this journal
Volume:
136
Issue:
35
Pages:
12355-12363
Publication date:
2014-09-01
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
Language:
English
Pubs id:
pubs:481014
UUID:
uuid:ab3d9940-aa1c-4fb7-aee1-f2cad6440566
Local pid:
pubs:481014
Source identifiers:
481014
Deposit date:
2014-08-23

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