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Vaccine escape recombinants emerge after pneumococcal vaccination in the United States

Abstract:

The heptavalent pneumococcal conjugate vaccine (PCV7) was introduced in the United States (US) in 2000 and has significantly reduced invasive pneumococcal disease; however, the incidence of nonvaccine serotype invasive disease, particularly due to serotype 19A, has increased. The serotype 19A increase can be explained in part by expansion of a genotype that has been circulating in the US prior to vaccine implementation (and other countries since at least 1990), but also by the emergence of a ...

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Authors


Brueggemann, AB More by this author
Journal:
PLoS Pathogens
Volume:
3
Issue:
11
Pages:
1628-1636
Publication date:
2007-11-05
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
URN:
uuid:ab3bbb5f-8cc0-4c75-8420-ad0c4421432d
Source identifiers:
92777
Local pid:
pubs:92777
Language:
English

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