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Glucosylceramide synthase inhibitors sensitise CLL cells to cytotoxic agents without reversing P-gp functional activity.

Abstract:

Malignant B-cells from most chronic lymphocytic leukaemia (CLL) patients over-express MDR1 encoded P-glycoprotein (P-gp) multidrug efflux pump. Inhibition of glucosylceramide (GC) synthesis has been shown in cell lines to correlate with the expression and function of P-gp and sensitise cancer cells to cytotoxic agents. We investigated the hypothesis that reducing intracellular GC levels will reduce P-gp expression in malignant cells from CLL patients. We studied the ability of glucosylceramid...

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Publication status:
Published

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Journal:
European journal of pharmacology
Volume:
609
Issue:
1-3
Pages:
34-39
Publication date:
2009-05-01
DOI:
EISSN:
1879-0712
ISSN:
0014-2999
Source identifiers:
101107

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