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Synthesis and α-Glucosidase II inhibitory activity of valienamine pseudodisaccharides relevant to N-glycan biosynthesis.

Abstract:
Valienol-derived allylic C-1 bromides have been used as carbaglycosyl donors for α-xylo configured valienamine pseudodisaccharide synthesis. We synthesised valienamine analogues of the Glc(α1→3)Glc and Glc(α1→3)Man disaccharides representing the linkages cleaved by α-Glucosidase II in N-glycan biosynthesis. These (N1→3)-linked pseudodisaccharides were found to have some α-Glucosidase II inhibitory activity, while two other (N1→6)-linked valienamine pseudodisaccharides failed to inhibit the enzyme.
Publication status:
Published

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Publisher copy:
10.1016/j.bmcl.2011.07.046
Journal:
Bioorganic and medicinal chemistry letters More from this journal
Volume:
21
Issue:
18
Pages:
5219-5223
Publication date:
2011-09-01
DOI:
EISSN:
1464-3405
ISSN:
0960-894X
Language:
English
Keywords:
Pubs id:
pubs:179475
UUID:
uuid:ab33b7de-c291-4028-9fd1-819f5ef348ef
Local pid:
pubs:179475
Source identifiers:
179475
Deposit date:
2012-12-19

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