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Journal article

Non-linear relationship between 5-HT transporter gene expression and frequency sensitivity of 5-HT signals.

Abstract:

Much evidence suggests that variation in expression of the 5-hydroxytryptamine (5-HT) transporter (5-HTT) is linked to risk of psychiatric illness, but the neurobiological basis of this association is uncertain. In this study, we investigated the impact of variation in 5-HTT expression on subsecond fluctuations in extracellular 5-HT concentrations ([5-HT](o) ). Stimulus-evoked [5-HT](o) was detected using fast-scan cyclic voltammetry at carbon-fibre microelectrodes in the substantia nigra in ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
Journal of neurochemistry
Volume:
115
Issue:
4
Pages:
965-973
Publication date:
2010-11-05
DOI:
EISSN:
1471-4159
ISSN:
0022-3042
URN:
uuid:ab322683-6b08-4e3b-989c-6657608727fd
Source identifiers:
114026
Local pid:
pubs:114026

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