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Factor H binding protein (fHbp)-mediated differential complement resistance of a serogroup C Neisseria meningitidis isolate from cerebrospinal fluid of a patient with invasive meningococcal disease

Abstract:

During an outbreak of invasive meningococcal disease (IMD) at the University of Southampton, UK, in 1997, two Neisseria meningitidis serogroup C isolates were retrieved from a student (‘Case’), who died of IMD, and a close contact (‘Carrier’) who, after mouth-to-mouth resuscitation on the deceased, did not contract the disease. Genomic comparison of the isolates demonstrated extensive nucleotide sequence identity, with differences identified in eight genes. Here, comparative proteomics was us...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1099/acmi.0.000255

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0001-9996-8107
Publisher:
Microbiology Society Publisher's website
Journal:
Access Microbiology Journal website
Volume:
3
Issue:
9
Article number:
000255
Publication date:
2021-09-09
Acceptance date:
2021-07-03
DOI:
EISSN:
2516-8290
Language:
English
Keywords:
Pubs id:
1185103
Local pid:
pubs:1185103
Deposit date:
2021-07-05

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