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Oncogenic B-RAF V600E signaling induces the T-Box3 transcriptional repressor to repress E-cadherin and enhance melanoma cell invasion

Abstract:

Approximately 50% of melanomas require oncogenic B-RAF V600E signaling for proliferation, survival, and metastasis, and the use of highly selective B-RAF inhibitors has yielded remarkable, although short-term, clinical responses. Reactivation of signaling downstream of B-RAF is frequently associated with acquired resistance to B-RAF inhibitors, and the identification of B-RAF targets may therefore provide new strategies for managing melanoma. In this report, we applied whole-genome expression...

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Publisher copy:
10.1038/jid.2012.421

Authors


Journal:
Journal of Investigative Dermatology More from this journal
Volume:
133
Issue:
5
Pages:
1269-1277
Publication date:
2013-05-01
DOI:
EISSN:
1523-1747
ISSN:
0022-202X
Language:
English
Pubs id:
pubs:405868
UUID:
uuid:ab21f39d-aa5c-457c-94f0-eb1ecc7c5b20
Local pid:
pubs:405868
Source identifiers:
405868
Deposit date:
2013-11-17

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