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Journal article

Tamoxifen administration in pregnant mice can be deleterious to both mother and embryo

Abstract:

Since it was introduced 20 years ago, tamoxifen-inducible genetic recombination in vivo has become a standard tool in many fields. This technique has great utility, allowing precise temporal and spatial gene recombination mediated by expression of a Cre recombinase-oestrogen receptor hormone binding domain fusion protein. It is frequently used in developmental biology, either for accurate spatio-temporal gene deletion or for lineage-labelling. Administration of high doses of tamoxifen can rap...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1177/0023677219856918

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
ORCID:
0000-0002-2069-7349
More from this funder
Name:
British Heart Foundation
Grant:
FS/17/55/33100
Publisher:
SAGE Publications
Journal:
Laboratory Animals More from this journal
Volume:
53
Issue:
6
Pages:
630-633
Publication date:
2019-06-27
Acceptance date:
2019-05-18
DOI:
EISSN:
1758-1117
ISSN:
0023-6772
Keywords:
Pubs id:
pubs:1002991
UUID:
uuid:ab2073bf-b14b-4ed3-8fbf-5807b20ad0f3
Local pid:
pubs:1002991
Source identifiers:
1002991
Deposit date:
2019-05-24

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