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Structural analysis and expression profile of a novel gene on chromosome 5q23 encoding a Golgi-associated protein with six splice variants, and involved within the 5q deletion of a Ph(-) CML patient.

Abstract:

We have identified a novel gene, upstream of the cytokine gene cluster region in 5q23-31, residing within one of the most common deleted segments associated with MDS. The novel gene exhibits significant alternative splicing generating at least six splice variants encoding four putative proline-rich protein isoforms, one of which is Golgi-associated. The gene is ubiquitously expressed and conserved among species with the C. elegans homologue being the most interesting, since it resides within ...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Journal:
Leukemia research More from this journal
Volume:
29
Issue:
1
Pages:
17-31
Publication date:
2005-01-01
DOI:
EISSN:
1873-5835
ISSN:
0145-2126
Language:
English
Keywords:
Pubs id:
pubs:32909
UUID:
uuid:ab1e73ba-9085-45f0-86e8-fa45f8a0f8fb
Local pid:
pubs:32909
Source identifiers:
32909
Deposit date:
2012-12-19

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