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Hepatocyte growth factor can substitute for M-CSF to support osteoclastogenesis.

Abstract:

Osteopetrotic mice lacking functional macrophage-colony stimulating factor (M-CSF) recover with ageing, suggesting that alternative osteoclastogenesis pathways exist. Hepatocyte growth factor (HGF) and M-CSF signal through tyrosine kinase receptors and phosphorylate common transducers and effectors such as Src, Grb2, and PI3-Kinase. HGF is known to play a role in osteoclast formation, and in this study we have determined whether HGF could replace M-CSF to support human osteoclastogenesis. We ...

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Publication status:
Published

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Publisher copy:
10.1016/j.bbrc.2006.09.076

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Biochemical and biophysical research communications More from this journal
Volume:
350
Issue:
2
Pages:
478-483
Publication date:
2006-11-01
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
Language:
English
Keywords:
Pubs id:
pubs:107457
UUID:
uuid:ab1e5773-241b-4c06-a38d-834e537fe6ab
Local pid:
pubs:107457
Source identifiers:
107457
Deposit date:
2012-12-19

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