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Distribution and metabolism in healthy volunteers of disodium azodisalicylate, a potential therapeutic agent for ulcerative colitis.

Abstract:

A series of experiments has been performed in healthy male volunteers to investigate the disposition of orally administered disodium azodisalicylate, a potentially useful drug for the treatment of ulcerative colitis. The drug was given by mouth in doses of up to 2 g a day for six weeks and there were no adverse effects. Serum concentrations of the intact compound were low and the serum half-time was 4-12.8 days, probably because of a combination of a low clearance rate and a high apparent vol...

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Publication status:
Published

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Publisher copy:
10.1136/gut.23.12.1081

Authors


Willoughby, CP More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences, PHC-Seniors
Truelove, SC More by this author
Journal:
Gut
Volume:
23
Issue:
12
Pages:
1081-1087
Publication date:
1982-12-05
DOI:
EISSN:
1468-3288
ISSN:
0017-5749
URN:
uuid:ab1a3dc2-1f9d-42eb-81f0-f408505ca648
Source identifiers:
322104
Local pid:
pubs:322104

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