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Journal article

Role of CD8 in aberrant function of cytotoxic T lymphocytes.

Abstract:

Using H-2Kd-restricted photoprobe-specific cytotoxic T lymphocyte (CTL) clones, which permit assessment of T cell receptor (TCR)-ligand interactions by TCR photoaffinity labeling, we observed that the efficiency of antigen recognition by CTL was critically dependent on the half-life of TCR-ligand complexes. We show here that antigen recognition by CTL is essentially determined by the frequency of serial TCR engagement, except for very rapid dissociations, which resulted in aberrant TCR signal...

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Publication status:
Published

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Publisher copy:
10.1084/jem.186.12.2033

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CCMP
Role:
Author
Journal:
Journal of experimental medicine More from this journal
Volume:
186
Issue:
12
Pages:
2033-2038
Publication date:
1997-12-01
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
Language:
English
Keywords:
Pubs id:
pubs:18469
UUID:
uuid:ab140a28-ebfa-40b7-82e8-07ea6aa84d27
Local pid:
pubs:18469
Source identifiers:
18469
Deposit date:
2012-12-19

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