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Role of CD8 in aberrant function of cytotoxic T lymphocytes.

Abstract:

Using H-2Kd-restricted photoprobe-specific cytotoxic T lymphocyte (CTL) clones, which permit assessment of T cell receptor (TCR)-ligand interactions by TCR photoaffinity labeling, we observed that the efficiency of antigen recognition by CTL was critically dependent on the half-life of TCR-ligand complexes. We show here that antigen recognition by CTL is essentially determined by the frequency of serial TCR engagement, except for very rapid dissociations, which resulted in aberrant TCR signal...

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Publication status:
Published

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Publisher copy:
10.1084/jem.186.12.2033

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP
Hudrisier, D More by this author
Cerottini, JC More by this author
Luescher, IF More by this author
Journal:
The Journal of experimental medicine
Volume:
186
Issue:
12
Pages:
2033-2038
Publication date:
1997-12-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:ab140a28-ebfa-40b7-82e8-07ea6aa84d27
Source identifiers:
18469
Local pid:
pubs:18469

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