- Abstract:
-
Using H-2Kd-restricted photoprobe-specific cytotoxic T lymphocyte (CTL) clones, which permit assessment of T cell receptor (TCR)-ligand interactions by TCR photoaffinity labeling, we observed that the efficiency of antigen recognition by CTL was critically dependent on the half-life of TCR-ligand complexes. We show here that antigen recognition by CTL is essentially determined by the frequency of serial TCR engagement, except for very rapid dissociations, which resulted in aberrant TCR signal...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1084/jem.186.12.2033
-
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- Journal:
- The Journal of experimental medicine
- Volume:
- 186
- Issue:
- 12
- Pages:
- 2033-2038
- Publication date:
- 1997-12-05
- DOI:
- EISSN:
-
1540-9538
- ISSN:
-
0022-1007
- URN:
-
uuid:ab140a28-ebfa-40b7-82e8-07ea6aa84d27
- Source identifiers:
-
18469
- Local pid:
- pubs:18469
- Copyright date:
- 1997
Journal article
Role of CD8 in aberrant function of cytotoxic T lymphocytes.
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