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Insights into β-cell biology and type 2 diabetes pathogenesis from studies of the islet transcriptome

Abstract:

Human β-cells play a pivotal role in the pathogenesis of type 2 diabetes (T2D). Consequently, improved understanding of the molecular and cellular processes critical to the normal function of these cells, and the ways in which these processes are disturbed during disease development, is central to efforts to develop novel therapeutic strategies. Detailed exploration of the transcriptomic, proteomic and metabolomic composition of islet cells provides a platform for defining cellular function. ...

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Publisher copy:
10.1159/000362471
Publisher:
S. Karger AG
Journal:
Frontiers in Diabetes More from this journal
Volume:
23
Pages:
111-121
Publication date:
2014-01-01
DOI:
EISSN:
1662-2995
ISSN:
0251-5342
Language:
English
Pubs id:
pubs:489462
UUID:
uuid:ab07193f-745c-4750-b1b5-ee36b571b265
Local pid:
pubs:489462
Source identifiers:
489462
Deposit date:
2015-01-13

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