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WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork.

Abstract:

Werner Syndrome is a premature aging disorder characterized by genomic instability, elevated recombination, and replication defects. It has been hypothesized that defective processing of certain replication fork structures by WRN may contribute to genomic instability. Fluorescence resonance energy transfer (FRET) analyses show that WRN and Flap Endonuclease-1 (FEN-1) form a complex in vivo that colocalizes in foci associated with arrested replication forks. WRN effectively stimulates FEN-1 cl...

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Publication status:
Published

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Publisher copy:
10.1091/mbc.e03-08-0567

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
Molecular biology of the cell More from this journal
Volume:
15
Issue:
2
Pages:
734-750
Publication date:
2004-02-01
DOI:
EISSN:
1939-4586
ISSN:
1059-1524
Language:
English
Keywords:
Pubs id:
pubs:130912
UUID:
uuid:aafe99f0-9b94-49de-8d27-83fad896f2d7
Local pid:
pubs:130912
Source identifiers:
130912
Deposit date:
2013-11-17

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