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Journal article

Effect of BET missense mutations on bromodomain function, inhibitor binding and stability

Abstract:

Lysine acetylation is an important epigenetic mark regulating gene transcription and chromatin structure. Acetylated lysine residues are specifically recognized by bromodomains, small protein interaction modules that read these modification in a sequence and acetylation dependent way regulating the recruitment of transcriptional regulators and chromatin remodelling enzymes to acetylated sites in chromatin. Recent studies revealed that bromodomains are highly druggable protein interaction doma...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Editor
Publisher:
Public Library of Science
Journal:
PLoS One More from this journal
Volume:
11
Issue:
7
Pages:
e0159180
Publication date:
2016-07-12
Acceptance date:
2016-06-28
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Pmid:
27403962
Language:
English
Keywords:
Pubs id:
pubs:634304
UUID:
uuid:aafc9bb5-ea72-46d3-9936-e1b58750b4d0
Local pid:
pubs:634304
Source identifiers:
634304
Deposit date:
2018-07-13

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