Journal article icon

Journal article

Structurally encoded intraclass differences in EphA clusters drive distinct cell responses.

Abstract:

Functional outcomes of ephrin binding to Eph receptors (Ephs) range from cell repulsion to adhesion. Here we used cell collapse and stripe assays, showing contrasting effects of human ephrinA5 binding to EphA2 and EphA4. Despite equivalent ligand binding affinities, EphA4 triggered greater cell collapse, whereas EphA2-expressing cells adhered better to ephrinA5-coated surfaces. Chimeric receptors showed that the ectodomain is a major determinant of cell response. We report crystal structures ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/nsmb.2617

Authors


Journal:
Nature structural and molecular biology More from this journal
Volume:
20
Issue:
8
Pages:
958-964
Publication date:
2013-08-01
DOI:
EISSN:
1545-9985
ISSN:
1545-9993
Language:
English
Keywords:
Pubs id:
pubs:410952
UUID:
uuid:aaf653a8-d5f9-45e4-a7a8-e65318b6510d
Local pid:
pubs:410952
Source identifiers:
410952
Deposit date:
2013-11-17

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP