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Journal article

Azithromycin versus placebo for the treatment of HIV-associated chronic lung disease in children and adolescents (BREATHE trial): study protocol for a randomised controlled trial.

Abstract:

Background

Human immunodeficiency virus (HIV)-related chronic lung disease (CLD) among children is associated with substantial morbidity, despite antiretroviral therapy. This may be a consequence of repeated respiratory tract infections and/or dysregulated immune activation that accompanies HIV infection. Macrolides have anti-inflammatory and antimicrobial properties, and we hypothesised that azithromycin would reduce decline in lung function and morbidity through preventing resp...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s13063-017-2344-2

Authors


Gonzalez-Martinez, C More by this author
Kranzer, K More by this author
Corbett, EL More by this author
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Publisher:
BioMed Central Publisher's website
Journal:
Trials Journal website
Volume:
18
Issue:
1
Pages:
622
Publication date:
2017-12-05
Acceptance date:
2017-11-08
DOI:
EISSN:
1745-6215
ISSN:
1745-6215
Pubs id:
pubs:817423
URN:
uri:aaf1e809-8578-453a-bc64-464eff0b26ac
UUID:
uuid:aaf1e809-8578-453a-bc64-464eff0b26ac
Local pid:
pubs:817423

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