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Autocrine IFNγ controls the regulatory function of lymphoproliferative double negative T cells.

Abstract:

TCRαβ(+) CD4(-)CD8(-)NK(-) double negative T cells (DN T cells) can act as regulatory T cells to inhibit allograft rejection and autoimmunity. Their role in graft-versus-host disease and mechanisms of suppression remain elusive. In this study, we demonstrate that DN T cells can inhibit CD4(+) T cell-mediated GVHD in a semi-allogeneic model of bone marrow transplantation. Furthermore, we present evidence of a novel autocrine IFNγ signaling pathway in Fas-deficient C57BL/6.lpr (B6.lpr) DN T cel...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Role:
Author
Publisher:
Public Library of Science
Journal:
PLoS ONE More from this journal
Volume:
7
Issue:
10
Pages:
e47732
Publication date:
2012-10-15
Acceptance date:
2012-09-14
DOI:
EISSN:
1932-6203
Language:
English
Keywords:
UUID:
uuid:aaf07c2e-5cf2-48f0-bc67-5620541af486
Local pid:
pubs:400589
Source identifiers:
400589
Deposit date:
2013-11-16

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