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SFRP2 is associated with increased adiposity and VEGF expression.

Abstract:

Aims

The aim of this study was to assess depot-specific expression and secretion of secreted frizzled-related protein 2 (sFRP2) by adipose tissue and its effect on adipocyte biology. We measured serum sFRP2 concentrations in 106 patients in vivo to explore its relationship to fat mass, glycaemia and insulin resistance.

Methods

Expression of sFRP2 in mouse and human tissues was assessed using polymerase chain reaction and Western blot. Western blot confirmed secret...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0163777

Authors


Crowley, RK More by this author
O'Reilly, MW More by this author
Bujalska, IJ More by this author
Hassan-Smith, ZK More by this author
Hazlehurst, JM More by this author
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Grant:
Summer Research Fellowship 2012
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS one Journal website
Volume:
11
Issue:
9
Pages:
e0163777
Publication date:
2016-09-05
Acceptance date:
2016-09-14
DOI:
ISSN:
1932-6203
Pubs id:
pubs:648014
URN:
uri:aaedfe14-9535-4cf4-abf7-96f34de10312
UUID:
uuid:aaedfe14-9535-4cf4-abf7-96f34de10312
Local pid:
pubs:648014
Language:
English
Keywords:

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